Effects of carbenoxolone sodium on stress-induced gastric damage in rats.

نویسندگان

  • W E Perkins
  • L Vars
چکیده

Carbenoxolone sodium was studied to determine its effect against restraint-induced gastric mucosal damage in the rat. Significant anti-ulcer activity was observed following intraperitoneal administration in nonfasted but not in either 24 or 48 h fasted rats. Orally, carbenoxolone had no statistically significant effect in non-fasted rats although the data suggest that it may have afforded some protection. These results indicate that the use of non-fasted rats is most probably a requirement for demonstrating the protective activity of this type of anti-ulcer compound in stressed rat assays.

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عنوان ژورنال:
  • British journal of pharmacology

دوره 47 4  شماره 

صفحات  -

تاریخ انتشار 1973